Modeling the Release Kinetics of Poorly Water-Soluble Drug Molecules from Liposomal Nanocarriers
نویسندگان
چکیده
منابع مشابه
Modeling the Release Kinetics of Poorly Water-Soluble Drug Molecules from Liposomal Nanocarriers
Liposomes are frequently used as pharmaceutical nanocarriers to deliver poorly water-soluble drugs such as temoporfin, cyclosporine A, amphotericin B, and paclitaxel to their target site. Optimal drug delivery depends on understanding the release kinetics of the drug molecules from the host liposomes during the journey to the target site and at the target site. Transfer of drugs in model system...
متن کاملModeling Drug-Carrier Interaction in the Drug Release from Nanocarriers
Numerous nanocarriers of various compositions and geometries have been developed for the delivery and release of therapeutic and imaging agents. Due to the high specific surface areas of nanocarriers, different mechanisms such as ion pairing and hydrophobic interaction need to be explored for achieving sustained release. Recently, we developed a three-parameter model that considers reversible d...
متن کاملSustained Release of Green Tea Polyphenols from Liposomal Nanoparticles; Release Kinetics and Mathematical Modelling
Background: Green tea polyphenols (GTP) are known to have several health benefits. In spite of these benefits, its application as a therapeutic agent is limited due to some of its limitations such as stability, bioavailability, and biotransformation. To overcome these limitations, liposomal nanoparticles have been used as a carrier of the GTP. <spa...
متن کاملPhysicochemical evaluation, study of stability and drug release kinetics from
Introduction: Acne is a disorder of the pilosebaceous unit of the skin and can present as non inflammatory and or inflammatory lesions. Tretinoin has been used therapeutically for over three decades. It is best known for its comedolytic effects on acne. It also inhibits comedone rupture, thus decreasing inflammatory events. Tretinoin is available in 0.01% to 0.1% as cream, gel or lotion. The ...
متن کاملFunctionalized carbon nanomaterials as nanocarriers for loading and delivery of a poorly water-soluble anticancer drug: a comparative study.
Carbon nanomaterials such as multiwalled carbon nanotubes (MWCNTs) and graphene oxide (GO) have been functionalized by highly hydrophilic and biocompatible poly(vinyl alcohol) (PVA) for loading and delivery of an anticancer drug, camptothecin (CPT). For the first time, CPT was loaded onto MWCNT-PVA and GO-PVA through π-π interactions and its capability to kill human breast and skin cancer cells...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Drug Delivery
سال: 2011
ISSN: 2090-3014,2090-3022
DOI: 10.1155/2011/376548